The Ultimate Kratom Experience
WHAT ACCOUNTS FOR THE VARIOUS EFFECTS OF KRATOM?
The 2 main alkaloids in Kratom that are responsible for mu opioid receptor activity are Mitragynine and 7 Hydroxymitragynine. 7ohm is the stronger of the 2. According to one study on lab rats, the Mu Opioid Receptor Score was 14 times higher than that of Morphine, and 7 times higher than that of Mitragynine. So, it appears that 7ohm is actually the main Opioid Receptor Agonist in Kratom, not Mitragynine as once thought.
This sampler covers the entire spectrum of alkaloid profiles found in Kratom. "Strains" in Indonesian Kratom culture are just blends of 4 different types of Kratom in varying proportions. The amount of oxidation that occurs determines what the alkaloid profile will be. Mitragynine, which is yellow/green, converts to 7 Hydroxymitragynine when oxidized. Thus, in order to get high levels of both Mitragynine and 7 Hydroxymitragynine, one must mix sun dried leaf, which naturally oxidizes, with leaf dried in the dark. Leaf dried in the dark has very little 7ohm (trace amounts), as it is not produced by the plant.
To make Kratom red in color, Indonesians cure the leaf in sealed plastic bags, which presumably ferments the leaf. However, fermentation and oxidation are quite different processes. The reason we think that red Kratom has higher levels of 7ohm is because the chemical itself is redish/brown in color. However, it is debatable whether these reds are more potent opioid agonists than sun dried greens (super green) because leaf in plastic bags are deprived oxygen when drying.
It appears that the level of oxidation of the leaf dictates what the effects will be. Although it is possible that genetics make a difference, they usually do not come into play because farmers are producing only one strain.