Monday, December 28, 2020

Could St. John's Wort potentiate the opioid effect in Kratom?

The enzyme responsible for converting Mitragynine into 7ohm is  CYP3A4. Mitragynine then inhibits the body's production of it. So, ti''s safe to say that more would be preferred to less when maximizing this chemical conversion process. Ironically, it is also the enzyme responsible for clearing the blood of almost 50% of all known drugs

It could be inferred then, that inducing production of this enzyme could increase the opioid effect by facilitating the conversion of Mitragynine, a weak opioid agonist, into 7ohm an opioid almost as strong as Morphine. Grapefruit juice actually inhibits this enzyme so, it should theoretically be avoided. Furthermore, acid degrades Mitragynine. Women naturally have more of this enzyme, as do diabetics. It is also induced by the following: 

St. John’s wort [14, 15, 16]

Capsaicin [17, 18]

Common valerian [19]

Echinacea purpurea [20]

Vitamin D and UV exposure [6]

Being female [21]

Diabetes [22]

Fatty acids [22]

Polycyclic aromatic hydrocarbons (PAH) found in cigarettes [23]

Aflatoxin B1 [24]

Some drugs such as carbamazepine [10] and dexamethasone [25]

Factors That Decrease CYP3A4

Food Components

Grapefruit juice (and its compounds bergamottin, naringenin, and paradicin-A) [26, 4, 27]

Starfruit juice [28]

Aloe vera juice [29]

Mixed vegetable juices [30]

Kale [31]

Garden cress [32, 33]

Fennel [34]

Green tea [4, 35]

Black pepper [36, 37]


Goldenseal [38]

Raspberry leaf [34]

Milk thistle (compounds silybin and isosilybin) [39]

Could it be that the effects of Kratom are mediated by the factors that affect this enzyme? 

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