Thursday, April 23, 2020

Molecular Docking Study shows Natural Compounds, including Epicatechin found in Kratom, that have Potential to Inhibit COVID 19 Protease

https://drive.google.com/open?id=1dqQvEdr6m33BwHjSHY8Fn-t1NT0vato_8Y4qXCe8-S8



The way of action studied is by inhibition of the COVID19 Protease (an enzyme that breaks down protein and is responsible for cell division). Binding energies were measured using a Docking Study. The baseline comparison values were from Nelfinavir and Lopinavir (antiretroviral drug for HIV). The study concluded that these drugs may be potential treatments for COVID19, as well as a host of other naturally occurring compounds from medicinal plants, based on the binding strength.  
"Therefore, nelfinavir and lopinavir may represent potential treatment options, and kaempferol, quercetin, luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenin-7-glucoside, oleuropein, curcumin, catechin, and epicatechin-gallate appeared to have the best potential to act as COVID-19 Mpro inhibitors. However, further research is necessary to investigate their potential medicinal use."

We should all be drinking Tea (Green and Black), which contains Quercetin, Epicatechin-gallate, and epicatechin. 
Kaempferol: kale, beans, tea, spinach and broccoli.
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Quercetin: broccoli, red onions, peppers, apples, grapes, black tea, green tea, red wine
luteolin-7-glucoside: mexican oregano, anises, and wild celeries and in a lower concentration in lentils, peppermints, and wild carrots
naringenin: grapefruit, bergamot, sour orange, tart cherries, tomatoes, cocoa, Greek oregano, water mint, drynaria as well as in beans.
demethoxycurcumin: cumin, ginger, curry powder
apigenin-7-glucoside: parsley, celery, celeriac, and chamomile tea are the most common sources. Apigenin is particularly abundant in the flowers of chamomile plants, constituting 68% of total flavonoids.
epicatechin-gallate: berries, chocolate, grapes, and tea; 

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