Thursday, April 23, 2020

Molecular Docking Study shows Natural Compounds, including Epicatechin found in Kratom, that have Potential to Inhibit COVID 19 Protease

The way of action studied is by inhibition of the COVID19 Protease (an enzyme that breaks down protein and is responsible for cell division). Binding energies were measured using a Docking Study. The baseline comparison values were from Nelfinavir and Lopinavir (antiretroviral drug for HIV). The study concluded that these drugs may be potential treatments for COVID19, as well as a host of other naturally occurring compounds from medicinal plants, based on the binding strength.  
"Therefore, nelfinavir and lopinavir may represent potential treatment options, and kaempferol, quercetin, luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenin-7-glucoside, oleuropein, curcumin, catechin, and epicatechin-gallate appeared to have the best potential to act as COVID-19 Mpro inhibitors. However, further research is necessary to investigate their potential medicinal use."

We should all be drinking Tea (Green and Black), which contains Quercetin, Epicatechin-gallate, and epicatechin. 
Kaempferol: kale, beans, tea, spinach and broccoli.
Quercetin: broccoli, red onions, peppers, apples, grapes, black tea, green tea, red wine
luteolin-7-glucoside: mexican oregano, anises, and wild celeries and in a lower concentration in lentils, peppermints, and wild carrots
naringenin: grapefruit, bergamot, sour orange, tart cherries, tomatoes, cocoa, Greek oregano, water mint, drynaria as well as in beans.
demethoxycurcumin: cumin, ginger, curry powder
apigenin-7-glucoside: parsley, celery, celeriac, and chamomile tea are the most common sources. Apigenin is particularly abundant in the flowers of chamomile plants, constituting 68% of total flavonoids.
epicatechin-gallate: berries, chocolate, grapes, and tea; 

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